Acute Thrombocytopenia after Initiating Anticoagulation with Rivaroxaban

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Acute thrombocytopenia after initiating anticoagulation with rivaroxaban.

A 75-year-old man with paroxysmal atrial fibrillation developed a traumatic intracranial hemorrhage during warfarin treatment. The administration of warfarin was stopped and rivaroxaban therapy, a novel oral anticoagulant (NOAC), was started. Immediately, his platelet count decreased to 3.7×10(4) /μL. The platelet count recovered rapidly after cessation of rivaroxaban administration. Developmen...

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Argatroban anticoagulation in patients with heparin-induced thrombocytopenia.

BACKGROUND Heparin-induced thrombocytopenia (HIT) is an intensely prothrombotic syndrome managed by discontinuation of heparin therapy and substitution of an alternative inhibitor of thrombin. We describe our experience with argatroban, a direct thrombin inhibitor, in patients with HIT or HIT with thrombosis (HITTS). METHODS In this multicenter, nonrandomized prospective study, 418 patients w...

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Safety of warfarin anticoagulation in patients with heparin-induced thrombocytopenia.

OBJECTIVES Venous limb gangrene has been reported to occur after high warfarin doses in heparin-induced thrombocytopenia (HIT), and this observation has been used to exclude warfarin management in this condition. The outcome of patients receiving modest doses of warfarin was studied. DESIGN Retrospective study of 114 consecutive HIT patients who received diagnoses by platelet aggregometry; 51...

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Association of rivaroxaban anticoagulation and spontaneous vitreous hemorrhage.

IMPORTANCE Rivaroxaban is an anticoagulant prescribed for the management of atrial fibrillation. We describe a correlation between rivaroxaban and spontaneous vitreous hemorrhage. OBSERVATIONS Three patients developed spontaneous vitreous hemorrhage after initiating rivaroxaban anticoagulation. All 3 patients were taking an additional anticoagulant at the time of hemorrhage. CONCLUSIONS AND...

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ژورنال

عنوان ژورنال: Internal Medicine

سال: 2014

ISSN: 0918-2918,1349-7235

DOI: 10.2169/internalmedicine.53.2890